Epigenetics: how cells remember past exposures
In the Jones lab, we are interested in how the epigenome serves as a kind of cellular memory. As the video below shows, sometimes during a sensitive period of development, an environmental exposure can change the epigenome. That change might then go on to influence possible health outcomes.
Do epigenetic memories of past exposures influence long term health?
The primary hypothesis we test is that environments in utero and in early life can leave behind differences or changes in the epigenome. These changes have been observed in human populations, but we don't know what they do or whether they have long term outcomes. Our research looks at the molecular links between these early life environments, epigenetic changes, and long term health outcomes.